OBINUTUZUMAB PLUS CHLORAMBUCIL VERSUS IBRUTINIB IN PREVIOUSLY UNTREATED CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITHOUT TP53 DISRUPTIONS: A REAL-LIFE CLL CAMPUS STUDY

One of the main issues in the treatment of patients with chronic lymphocytic leukemia (CLL) deals with the choice between continuous or fixed-duration therapy.Continuous ibrutinib (IB), the first-in-class BTK inhibitor, and obinutuzumab-chlorambucil (G-CHL) are commonly used therapies for elderly and/or comorbid patients.No head-to-head comparison

Background and Objectives: The selective kappa opioid receptor agonist U50,488 was reported to have analgesic, cough suppressant, diuretic and other beneficial properties.The aim Toggle Switches of our study was to analyze the effects of some original chitosan-coated liposomes entrapping U50,488 in somatic and visceral nociceptive sensitivity in mi

Introduction: Adherence to infection control practices are crucial for neonatal care.Objectives: To describe the adherence to clean birth and postnatal care practices by healthcare workers in selected procedures in major hospitals in a district of Sri Lanka Methods: This was a qualitative observational study.The Face Powder study sample comprised h

Hollow sandcrete blocks constitute more than 90% of residential building construction in developing countries especially in West Africa.Over-reliance on dredged river sands and conventional ordinary Portland cement (OPC) contributes to environmental degradation and post-construction problems such as swelling and shrinkage-induced cracks prevalent i

Fraxinus species belongs to the Oleaceae family, commonly known as Ash tree, and has been utilized as a folk medicine with various medicinal properties, including anti-obesity activity.The goal of the present study IBS RELIEF BIOTIC was to establish quality control parameters using microscopic characterization, phytochemical differentiation, and an